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As is well-known, "advice questions" are generally subject to greater scrutiny as regarding appropriateness for MO.
I certainly think the question is highly subjective. What sorts of problems one tackles, and especially whether one "should" tackle the hard open questions, is very much related to the individual personality. There are some who love to tackle the big ones (Paul Cohen, John Nash, and de Branges all come to mind), with varying degrees of success, and I think that's a personality thing. But there is no way of giving a one-size-fits-all answer.
The answers that have appeared so far are good, but good in a very general piece-of-wisdom way, and absolutely the types of answers one would expect. I don't think there is much chance of improving on them, as general wisdom goes.